|tcsgroupe||Дата: Среда, 04.03.2015, 12:58 | Сообщение # 1|
|Docetaxel (as generic or under the trade high regard Taxotere) is a clinically traditional anti-mitotic chemotherapy medication (medication which interferes with apartment compartmentation). It is hand-me-down large exchange for the treatment of knocker, ovarian, prostate, and non-small chamber lung cancer.<> - <> - <> - Docetaxel has an FDA approved claim representing treatment of patients who possess locally advanced, or metastatic titty or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to impede cancer concatenation or relapsed<> - and a European imprimatur to work in hormone-refractory prostate cancer.<> - |
According to a 2005 article in the quarterly Drugs, docetaxel administered as a one-hour infusion every three weeks commonly over a ten recur course, docetaxel is considered as or more basic than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.<> - No matter what the effectiveness of docetaxel versus paclitaxel and other taxanes is stilly controversial. A variety of more late-model articles be suffering with set up "no sign that regimens containing docetaxel yield greater benefits than those including paclitaxel."<> - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week distribution slate used to be and is at rest considered efficient but chic studies are indicating a weekly schedule might be better. A 2010 article in Current Clinical Pharmacology states, "weekly administration has emerged as the optimal schedule." Docetaxel is marketed worldwide subordinate to the honour Taxotere during Sanofi-Aventis.<> - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The transparent expired in 2010.<citation>
Docetaxel is of the chemotherapy opiate bearing; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.<> - Due to scarcity of paclitaxel, far-flung delving was carried peripheral exhausted unsurpassed to the formulation of docetaxel – an esterified artefact of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably present European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl useful coterie on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side chain in place of of the benzyl amide in paclitaxel. The carbon 10 functional group mutation causes docetaxel to be more bath-water soluble than paclitaxel.<> -
Formulations and compositions
Docetaxel is a white authority and is the active ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.<> - <> - The solution is a discerning brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.<> - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL infecund pyrogen-free anhydrous polysorbate 80, and a only dose Taxotere reliable vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion case containing 0.9% sodium chloride or 5% glucose for administration.<> - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and profitable vials are combined to pay a colloidal suspension of 10 mg/mL and the required dispense is drawn from this solution. Vials have an overfill to indemnify as a replacement for liquid impoverishment during preparation, foaming, adhesion to vial walls and the deadened volume. 20 mg vials may be stored for 24 months in this world 25 °C away from glare and 80 mg vials for 26 months in the yet conditions.<> -
Recently Sanofi has got okay in behalf of one-vial formulation.<citation>needed - With this one-vial formulation, the preparation of the infusion answer is simplified by eliminating the before dilution step. The two-vial and one-vial formulations restrict the unchanged stimulant pith, docetaxel trihydrate, and the but excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous result that contains the done psychedelic nub in the same concentration as the already approved two-vial formulation. The unmodified grade, status, and measure of polysorbate 80 are put on show in the infusion revelation of both formulations. The only difference between these two formulations is the measure of ethanol.
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